[I124] Radiobiological model-based treatment individualisation in radiotherapy
نویسندگان
چکیده
منابع مشابه
Radiobiological Model in Radiotherapy Planning for Prostate Cancer Treatment
Quantitative radiobiological models can be used to assess the optimum clinical outcome from sophisticated therapeutic modalities by calculating tumor control probability (TCP) and normal tissue complication probability (NTCP). In this study two 3D-CRT and an IMRT treatment plans were developed with an initial prescription dose of 60 Gy in 2 Gy/fraction to prostate. Sensitivity of TCP and Compli...
متن کاملTowards Multidimensional Radiotherapy: Key Challenges for Treatment Individualisation
Functional and molecular imaging of tumours have offered the possibility of redefining the target in cancer therapy and individualising the treatment with a multidimensional approach that aims to target the adverse processes known to impact negatively upon treatment result. Following the first theoretical attempts to include imaging information into treatment planning, it became clear that the ...
متن کامل[Radiobiological pitfalls of new techniques in radiotherapy].
Radiotherapy techniques in the last decade evolved to the stage where the potential dose distribution significantly differs from earlier practices. Rotational IMRT, robotic radiotherapy or proton radiotherapy enables extremely precise dose delivery to target volumes, on the other hand, these techniques can yield a number of problems. As for photon radiotherapy, this concerns primarily the effec...
متن کاملInvestigation into the radiobiological consequences of pre-treatment verification imaging with megavoltage X-rays in radiotherapy.
OBJECTIVE The aim of this study was to investigate the effect of pre-treatment verification imaging with megavoltage X-rays on cancer and normal cell survival in vitro and to compare the findings with theoretically modelled data. Since the dose received from pre-treatment imaging can be significant, the incorporation of this dose at the planning stage of treatment has been suggested. METHODS ...
متن کاملUse of Radiobiological Modeling in Treatment Plan Evaluation and Optimization of Prostate Cancer Radiotherapy
There are many tools available that are used to evaluate a radiotherapy treatment plan, such as isodose distribution charts, dose volume histograms (DVH), maximum, minimum and mean doses of the dose distributions as well as DVH point dose constraints. All the already mentioned evaluation tools are dosimetric only without taking into account the radiobiological characteristics of tumors or OARs....
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ژورنال
عنوان ژورنال: Physica Medica
سال: 2018
ISSN: 1120-1797
DOI: 10.1016/j.ejmp.2018.06.196